Myocardial preservation with glucose, insulin, and potassium: Reply

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[Glucose--insulin--potassium (GIK) in acute myocardial infarction].

Myocardial Infarction To the Editor: As my mentor Dr William Dock said, medical practice is like a pendulum: it swings back and forth every 20 to 30 years. Sodi-Pallares et al1 in 1962 introduced the glucose-insulinpotassium infusion (GIK) for treatment of acute myocardial infarction. It was also called the “polarizing solution,”2 but little did they know that this solution indeed polarized the...

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Glucose-Insulin-Potassium Therapy for Treatment of Acute Myocardial Infarction

authors and five references. They should not have tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Only some letters will be published. Authors of those selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed i...

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Effect of glucose-insulin-potassium infusion on thallium myocardial clearance.

Factors influencing the rate of 201Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net 201Tl clearance rates from myocardium with and without initial 201Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous...

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Effects of glucose and glucose-insulin-potassium on haemodynamics and enzyme release after acute myocardial infarction.

The effects on haemodynamics and infarct size (measured by total creatine kinase release) of intravenous infusions of normal saline, glucose, or glucose-insulin-potassium were studied in 36 patients with transmural acute myocardial infarction qf less than 12 hours' duration. In 12 patients, 2 ml/kg 50 per cent glucose (5.55 mmol/kg) was given over 10 minutes with 0 4 unit/kg soluble insulin 5 m...

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Preconditioning with glucose-insulin-potassium solution and restoration of myocardial function during coronary surgery.

The administration of glucose-insulin-potassium (GIK) solution has beeen shown to exert cardioprotective and immunomodulatory properties in coronary disease. 49 patients (pts.) for coronary surgery were randomly assigned to receive high-dose GIK treatment (30% glucose, insulin 2 IU.kg(-1).l(-1) and K(+) 80 mmo/l solution; 1 ml/kg/h); low-dose GIK treatment (10% glucose, insulin 32 IU l(-1) and ...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 1985

ISSN: 0022-5223

DOI: 10.1016/s0022-5223(19)38710-0